AR

Across TCGA patient cohorts, AR mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. COAD shows the largest number of these associations.

The most reproducible AR-associated genes across cancer lineages are eIF4E, HER2_pY1248, and mTOR_pS2448. Each is linked with AR in more than 2 cancer types. Because this analysis shows association rather than direction, both AR-to-partner and partner-to-AR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AR-low versus AR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AR→partner) and Y-score (partner→AR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.174	+3.459	.005	.004	3	2
COAD	HER2_pY1248 →	-0.228	-2.000	.008	.027	3	2
COAD	mTOR_pS2448 →	-0.160	-3.304	.011	.009	3	2
COAD	14-3-3_epsilon →	+0.171	+2.545	<.001	<.001	3	2
COAD	TAZ →	+0.144	+2.025	.037	.005	3	2
COAD	ATM →	-0.325	-1.576	.018	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by AR expression — COAD

Explore this box plot interactively →