AR

Across TCGA cell cohorts, AR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,354 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AR-associated GO terms across cancer lineages are Cellular response to testosterone stimulus, Muscle cell apoptotic process, and High-density lipoprotein particle remodeling. Each is linked with AR in more than 8 cancer types. Because this analysis shows association rather than direction, both AR-to-partner and partner-to-AR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to testosterone stimulus grouped by AR-low versus AR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AR→partner) and Y-score (partner→AR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to testosterone stimulus →	-0.218	-1.833	<.001	<.001	3	9
BREAST	Muscle cell apoptotic process →	+0.112	+1.684	.001	.004	3	8
LIVER	High-density lipoprotein particle remodeling →	-0.432	-1.584	.008	.007	2	8
LIVER	Cytosolic transport →	+0.049	+1.650	.009	.008	3	7
BONE	Schwann cell differentiation →	+0.120	+1.453	.003	<.001	3	6
SOFT_TISSUE	Substantia nigra development →	+0.069	+1.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,354 associations by consensus.

Cellular response to testosterone stimulus by AR expression — BONE

Explore this box plot interactively →