AR

Across TCGA cell cohorts, AR mutation is significantly associated with the RNA expression of many other genes, with 198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AR-associated genes across cancer lineages are GPR101, OPRPN, and HBM. Each is linked with AR in more than 1 cancer types. Because this analysis shows association rather than direction, both AR-to-partner and partner-to-AR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by AR-low versus AR-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AR→partner) and Y-score (partner→AR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPR101 →	+0.012	+3.990	.003	.003	3	2
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1
URINARY_TRACT	HBM →	+0.042	+4.087	<.001	.009	3	1
BREAST	IFNK →	+0.019	+4.614	<.001	<.001	3	1
BREAST	ACTL9 →	+0.008	+4.196	<.001	.006	3	1
BREAST	H2AB1 →	+0.488	+3.758	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

GPR101 by AR expression — OVARY

Explore this box plot interactively →