AQP8

Across TCGA patient cohorts, AQP8 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,185 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible AQP8-associated proteins across cancer lineages are ALDH18A1, FCGR3A, and SLC4A4_S1026. Each is linked with AQP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both AQP8-to-partner and partner-to-AQP8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AQP8 versus ALDH18A1 in BRCA, with a Pearson correlation of -0.24.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP8→partner) and Y-score (partner→AQP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ALDH18A1 →	-0.371	-0.134	<.001	.001	3	3
COAD	FCGR3A →	-1.241	-3.063	<.001	<.001	3	3
LSCC	SLC4A4_S1026 →	+1.168	+0.148	<.001	<.001	3	3
LSCC	SLC4A4_S213 →	+1.119	+0.094	.002	.003	3	3
LSCC	SLC4A4_S257 →	+1.119	+0.094	.002	.003	3	3
LSCC	SLC4A4_S68 →	+1.007	+0.135	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,185 associations by consensus.

AQP8 vs ALDH18A1 — BRCA

Explore this scatter interactively →