AQP8

Across TCGA patient cohorts, AQP8 protein abundance is significantly associated with the RNA expression of many other genes, with 3,926 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible AQP8-associated genes across cancer lineages are P2RX1, UPB1, and LGALS2. Each is linked with AQP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP8-to-partner and partner-to-AQP8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AQP8 versus P2RX1 in PDAC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP8→partner) and Y-score (partner→AQP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	P2RX1 →	+0.884	+1.192	<.001	<.001	3	2
PDAC	UPB1 →	-0.160	-0.954	<.001	.001	3	1
PDAC	LGALS2 →	+0.970	+0.853	.001	.005	3	1
PDAC	HIRA →	-0.164	-0.874	.006	.003	3	1
PDAC	DDHD1 →	-0.279	-0.990	.002	.003	3	1
PDAC	TCL1A →	-0.729	-1.012	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,926 associations by consensus.

AQP8 vs P2RX1 — PDAC

Explore this scatter interactively →