AQP8

Across TCGA patient cohorts, AQP8 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP8-associated genes across cancer lineages are p27_pT157, p62 Lck ligand, and Rad50. Each is linked with AQP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP8-to-partner and partner-to-AQP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by AQP8-low versus AQP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP8→partner) and Y-score (partner→AQP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT157 →	-0.064	-2.321	.028	.035	3	1
UCEC	p62 Lck ligand →	+0.366	+2.321	.025	.035	3	1
UCEC	Rad50 →	-0.249	-2.321	.040	.035	3	1
UCEC	Tuberin →	+0.325	+2.321	.016	.035	3	1
UCEC	Bid →	-0.132	-3.000	.028	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.793	+3.189	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p27_pT157 by AQP8 expression — UCEC

Explore this box plot interactively →