AQP5

Across TCGA pan-cancer cohorts, AQP5 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated AQP5 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher AQP5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AQP5 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC and LSCC are the cancer types where AQP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.827	0.570	.026	8	view →
LSCC	OS	Tertile	All	0.936	1.000	.046	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

AQP5–PDAC (DFS)

Open the PDAC breakdown →