AQP4-AS1

Across TCGA pan-cancer cohorts, AQP4-AS1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated AQP4-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher AQP4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AQP4-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, HNSC, and KIRC are the cancer types where AQP4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.727	0.949	.004	80	view →
HNSC	OS	Tertile	III,IV	0.439	0.304	.008	58	view →
KIRC	OS	Median	All	0.694	0.569	.002	44	view →
DLBC	DFS	Tertile	III,IV	0.070	0.799	<.001	42	view →
BRCA	OS	Tertile	All	0.979	0.940	.001	38	view →
UCEC	OS	Tertile	All	0.848	0.926	.005	28	view →
PAAD	DFS	Quartile	All	0.479	0.171	<.001	22	view →
READ	OS	Tertile	IV	0.331	0.824	<.001	22	view →
LUAD	OS	Quartile	All	0.495	0.319	.017	18	view →
ACC	OS	Tertile	IV	0.837	0.401	.017	18	view →
ESCA	OS	Median	III,IV	0.563	0.349	.011	12	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

AQP4-AS1–UVM (OS)

Open the UVM breakdown →