AQP4-AS1

Across TCGA pan-cancer cohorts, AQP4-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AQP4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where AQP4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types AQP4-AS1 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and KIRP are the cancer types where AQP4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AQP4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.380	<.001	11	view →
KICH	Male	II,III,IV	−0.210	<.001	8	view →
KIRP	All	II,III,IV	−0.145	.001	7	view →
HNSC	All	All	−0.174	.001	6	view →
LUSC	All	All	−0.265	.001	5	view →
COAD	All	II,III,IV	−0.016	<.001	5	view →
STAD	All	II,III,IV	−0.061	.020	3	view →
READ	All	All	−0.020	.001	3	view →
THCA	Male	III,IV	−0.430	.018	2	view →
PRAD	All	All	+0.108	.032	2	view →
ESCA	All	All	−0.150	.027	1	view →
KIRC	All	All	+0.092	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AQP4-AS1–LUAD

Open the LUAD breakdown →