AQP3

Across TCGA cell cohorts, AQP3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible AQP3-associated genes across cancer lineages are CLEC4G, IDI2, and ASB17. Each is linked with AQP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP3-to-partner and partner-to-AQP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC4G grouped by AQP3-low versus AQP3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP3→partner) and Y-score (partner→AQP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLEC4G →	+0.022	+5.415	<.001	.004	3	1
OVARY	IDI2 →	+0.021	+4.029	.001	.009	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.020	+4.169	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CLEC4G by AQP3 expression — SKIN

Explore this box plot interactively →