Across TCGA patient cohorts, AQP12A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP12A-associated genes across cancer lineages are p62 Lck ligand, Annexin-1, and Bcl-2. Each is linked with AQP12A in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP12A-to-partner and partner-to-AQP12A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP12A→partner) and Y-score (partner→AQP12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.511	+3.009	.004	.019	3	1
UCEC	Annexin-1 →	+0.951	+3.019	<.001	.019	3	1
UCEC	Bcl-2 →	-0.528	-2.980	.005	.036	3	1
UCEC	cIAP →	+0.176	+2.817	.019	.036	3	1
UCEC	eIF4E →	+0.265	+3.169	.022	.020	1	1
UCEC	ERK2 →	+0.263	+3.169	.013	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

AQP12A survival (RNA) · tumor vs normal (RNA) · all AQP12A data types