AQP11

Across TCGA pan-cancer cohorts, AQP11 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AQP11 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AQP11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AQP11 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

HNSC, BRCA, and BLCA are the cancer types where AQP11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.013	0.768	<.001	48	view →
BRCA	OS	Median	III,IV	0.146	0.833	<.001	24	view →
BLCA	DFS	Median	All	1.000	0.323	.012	12	view →
SKCM	DFS	Median	All	0.244	0.730	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

AQP11–HNSC (OS)

Open the HNSC breakdown →