AQP10

Across TCGA patient cohorts, AQP10 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP10-associated genes across cancer lineages are JNK_pT183_Y185, GSK3-a-b, and mTOR. Each is linked with AQP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP10-to-partner and partner-to-AQP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by AQP10-low versus AQP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP10→partner) and Y-score (partner→AQP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.197	-3.169	.009	.019	3	2
SKCM	GSK3-a-b →	+0.224	+3.000	.011	.036	2	2
SKCM	mTOR →	+0.310	+3.000	.024	.036	3	1
UCEC	Heregulin →	-0.124	-2.321	.025	.034	3	1
UCEC	Ku80 →	+0.374	+3.820	<.001	<.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.591	-2.700	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK_pT183_Y185 by AQP10 expression — UCEC

Explore this box plot interactively →