AQP10

Across TCGA pan-cancer cohorts, AQP10 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated AQP10 data layer compared with 6 for mutation status.

The strongest signal is observed in thymoma (THYM), where higher AQP10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AQP10 expression acts as an unfavorable survival marker, although some lineages such as BLCA and COAD show a favorable association.

THYM, UVM, and BLCA are the cancer types where AQP10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	II,III,IV	0.710	0.965	.001	57	view →
UVM	OS	Tertile	III,IV	0.241	0.765	.002	45	view →
BLCA	DFS	Median	All	0.574	0.448	.003	32	view →
LIHC	OS	Quartile	All	0.626	0.893	<.001	28	view →
DLBC	OS	Tertile	II,III,IV	0.279	1.000	.003	26	view →
UCS	DFS	Median	IV	0.367	0.952	.001	24	view →
LGG	DFS	Quartile	All	0.325	0.493	.008	19	view →
KIRC	DFS	Median	IV	0.201	0.426	.001	18	view →
LAML	DFS	Median	All	0.283	0.474	.011	18	view →
KICH	OS	Tertile	II,III,IV	0.178	0.876	<.001	18	view →
TGCT	DFS	Median	All	0.522	0.814	<.001	18	view →
COAD	DFS	Tertile	All	0.778	0.650	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

AQP10–THYM (DFS)

Open the THYM breakdown →