AQP10

Across TCGA cell cohorts, AQP10 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AQP10-associated genes across cancer lineages are CDX4, KRTAP10-2, and OCM2. Each is linked with AQP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP10-to-partner and partner-to-AQP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDX4 grouped by AQP10-low versus AQP10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP10→partner) and Y-score (partner→AQP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDX4 →	+0.009	+3.632	<.001	.003	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.054	+3.994	<.001	.002	3	1
LUNG_NSCLC_LUAD	OCM2 →	+0.069	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PMIS2 →	+0.038	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CDX4 by AQP10 expression — LARGE_INTESTINE

Explore this box plot interactively →