APPL1

Across TCGA patient cohorts, APPL1 mutation is significantly associated with the RNA expression of many other genes, with 4,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APPL1-associated genes across cancer lineages are CRK, MAP2K1, and CNTROB. Each is linked with APPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both APPL1-to-partner and partner-to-APPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRK grouped by APPL1-low versus APPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL1→partner) and Y-score (partner→APPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRK →	+0.308	+1.928	.002	<.001	3	3
UCEC	MAP2K1 →	+0.556	+1.709	<.001	<.001	3	3
COAD	CNTROB →	+0.604	+3.371	<.001	.004	3	3
UCEC	PPP2R2D →	+0.294	+2.168	<.001	<.001	3	3
UCEC	NCAPH2 →	+0.580	+3.544	<.001	<.001	3	3
UCEC	MCM10 →	+0.608	+2.547	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,299 associations by consensus.

CRK by APPL1 expression — UCEC

Explore this box plot interactively →