APP

Across TCGA patient cohorts, APP mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APP-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and PCNA. Each is linked with APP in more than 1 cancer types. Because this analysis shows association rather than direction, both APP-to-partner and partner-to-APP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by APP-low versus APP-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APP→partner) and Y-score (partner→APP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.194	+3.021	.005	.018	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.398	.002	.004	3	2
UCEC	PCNA →	+0.154	+1.222	.012	.011	3	2
COAD	BRCA2 →	+0.289	+3.169	.012	.019	3	1
UCEC	eIF4E →	+0.139	+2.335	.020	.002	3	1
UCEC	A-Raf_pS299 →	-0.095	-1.502	.005	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-E2 by APP expression — STAD

Explore this box plot interactively →