APP

Across TCGA cell cohorts, APP mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APP-associated genes across cancer lineages are OR10W1, DBX1, and USP17L17. Each is linked with APP in more than 1 cancer types. Because this analysis shows association rather than direction, both APP-to-partner and partner-to-APP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by APP-low versus APP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APP→partner) and Y-score (partner→APP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR10W1 →	+0.019	+4.058	<.001	.009	3	2
URINARY_TRACT	DBX1 →	+0.006	+5.087	<.001	.004	3	1
STOMACH	USP17L17 →	+0.013	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	SPRR4 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TMEM202 →	+0.033	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	FAM47B →	+0.013	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

OR10W1 by APP expression — BLOOD_Lymphoma

Explore this box plot interactively →