APOOP5

Across TCGA pan-cancer cohorts, APOOP5 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated APOOP5 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher APOOP5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated APOOP5 expression acts as an unfavorable survival marker, although some lineages such as ACC and BLCA show a favorable association.

DLBC, ACC, and LUAD are the cancer types where APOOP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.520	1.000	.003	48	view →
ACC	DFS	Tertile	III,IV	0.641	0.188	.006	46	view →
LUAD	OS	Tertile	II,III,IV	0.599	0.730	.013	39	view →
KIRC	OS	Quartile	All	0.531	0.664	.011	20	view →
THYM	DFS	Tertile	II,III,IV	0.574	0.911	.002	18	view →
BLCA	DFS	Tertile	All	0.815	0.553	.019	18	view →
SKCM	DFS	Quartile	II,III,IV	0.481	0.252	.007	15	view →
KICH	OS	Tertile	All	0.917	1.000	.014	10	view →
ESCA	DFS	Quartile	All	0.404	0.604	.025	10	view →
UVM	DFS	Tertile	III,IV	0.196	0.578	.035	9	view →
THCA	DFS	Tertile	IV	0.075	0.807	<.001	9	view →
UCEC	OS	Median	III,IV	0.712	0.491	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

APOOP5–DLBC (OS)

Open the DLBC breakdown →