APOOP5

Across TCGA pan-cancer cohorts, APOOP5 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of APOOP5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where APOOP5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOOP5 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

COAD, HNSC, and KIRP are the cancer types where APOOP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOOP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.059	.011	3	view →
HNSC	All	III,IV	+0.020	.032	3	view →
KIRP	Male	All	−0.021	.006	2	view →
BLCA	All	All	+0.016	.041	2	view →
KIRC	All	II,III,IV	−0.008	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

APOOP5–COAD

Open the COAD breakdown →