APOOP4

Across TCGA pan-cancer cohorts, APOOP4 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated APOOP4 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher APOOP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOOP4 expression acts as an unfavorable survival marker.

OV, LIHC, and LUAD are the cancer types where APOOP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Quartile	II,III,IV	0.449	0.569	.002	54	view →
LIHC	OS	Tertile	II,III,IV	0.174	0.456	.006	48	view →
LUAD	OS	Tertile	II,III,IV	0.297	0.605	.010	36	view →
BLCA	OS	Tertile	IV	0.095	0.608	<.001	18	view →
READ	DFS	Tertile	III,IV	0.342	0.593	.014	18	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
KIRC	OS	Tertile	All	0.734	0.822	.049	9	view →
COAD	OS	Tertile	IV	0.383	0.682	.033	9	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

APOOP4–OV (DFS)

Open the OV breakdown →