APOOP4

Across TCGA pan-cancer cohorts, APOOP4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of APOOP4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where APOOP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOOP4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LUSC, KICH, and KIRC are the cancer types where APOOP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOOP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.060	.001	6	view →
KICH	All	All	−0.040	.010	2	view →
KIRC	All	III,IV	−0.031	.006	2	view →
COAD	All	II,III,IV	+0.028	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

APOOP4–LUSC

Open the LUSC breakdown →