APOOP2

Across TCGA pan-cancer cohorts, APOOP2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated APOOP2 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher APOOP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOOP2 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

THCA, KIRC, and COAD are the cancer types where APOOP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	All	0.346	0.831	<.001	144	view →
KIRC	DFS	Tertile	IV	0.227	0.512	.008	78	view →
COAD	DFS	Tertile	IV	0.241	0.515	.009	54	view →
UCEC	OS	Tertile	All	0.304	0.714	.002	54	view →
READ	OS	Tertile	IV	0.111	0.893	<.001	45	view →
LIHC	OS	Tertile	II,III,IV	0.320	0.705	.002	45	view →
LUAD	OS	Tertile	III,IV	0.223	0.677	.006	36	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
ESCA	OS	Tertile	II,III,IV	0.111	0.925	.018	24	view →
LUSC	OS	Tertile	III,IV	0.179	0.712	.020	15	view →
BLCA	DFS	Median	IV	0.612	0.324	.019	7	view →
BRCA	OS	Tertile	II,III,IV	0.864	0.918	.047	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

APOOP2–THCA (DFS)

Open the THCA breakdown →