APOLD1

Across TCGA patient cohorts, APOLD1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOLD1-associated genes across cancer lineages are Ku80, 4E-BP1, and eIF4G. Each is linked with APOLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOLD1-to-partner and partner-to-APOLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by APOLD1-low versus APOLD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOLD1→partner) and Y-score (partner→APOLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.299	+2.817	.021	.036	3	1
UCEC	4E-BP1 →	+0.382	+2.837	.010	.035	3	1
UCEC	eIF4G →	+0.430	+3.000	.011	.036	2	1
UCEC	Shc_pY317 →	-0.232	-3.169	.005	.020	2	1
UCEC	Tuberin →	+0.319	+3.009	.031	.019	2	1
UCEC	MEK1 →	+0.493	+3.169	.014	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by APOLD1 expression — UCEC

Explore this box plot interactively →