APOLD1

Across TCGA pan-cancer cohorts, APOLD1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of APOLD1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where APOLD1 RNA is repressed in tumor relative to normal tissue. In most cancer types APOLD1 is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

BLCA, KIRC, and KIRP are the cancer types where APOLD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOLD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−2.115	<.001	11	view →
KIRC	Female	All	+2.248	<.001	10	view →
KIRP	Male	II,III,IV	−1.991	<.001	9	view →
LIHC	Female	II,III,IV	+1.358	<.001	9	view →
LUSC	All	II,III,IV	−1.826	<.001	8	view →
LUAD	Female	All	−1.319	<.001	8	view →
UCEC	All	III,IV	−2.796	<.001	6	view →
BRCA	All	III,IV	−1.668	<.001	6	view →
KICH	All	All	−0.947	.003	6	view →
COAD	All	All	+0.825	.003	3	view →
THCA	All	IV	−2.502	.039	1	view →
CHOL	All	All	+1.037	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

APOLD1–BLCA

Open the BLCA breakdown →