APOLD1

Across TCGA cell cohorts, APOLD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,460 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOLD1-associated GO terms across cancer lineages are Positive regulation of L-glutamate import across plasma membrane, Protein polyubiquitination, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with APOLD1 in more than 10 cancer types. Because this analysis shows association rather than direction, both APOLD1-to-partner and partner-to-APOLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of L-glutamate import across plasma membrane grouped by APOLD1-low versus APOLD1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOLD1→partner) and Y-score (partner→APOLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of L-glutamate import across plasma membrane →	+0.059	+0.903	.001	<.001	3	11
LUNG_SCLC	Protein polyubiquitination →	+0.038	+1.188	.001	.002	3	10
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.108	+1.344	<.001	<.001	3	10
LUNG_SCLC	Negative regulation of cilium assembly →	+0.101	+1.401	<.001	<.001	3	9
BREAST	Cell division →	+0.065	+0.845	<.001	<.001	3	9
LUNG_SCLC	Regulation of ubiquitin-protein transferase activity →	+0.155	+1.778	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,460 associations by consensus.

Positive regulation of L-glutamate import across plasma membrane by APOLD1 expression — BREAST

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