APOL5

Across TCGA pan-cancer cohorts, APOL5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated APOL5 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher APOL5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOL5 expression acts as an unfavorable survival marker.

LUAD, PDAC, and GBM are the cancer types where APOL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.217	1.000	.022	7	view →
PDAC	DFS	Median	III,IV	0.500	1.000	.022	2	view →
GBM	OS	Quartile	All	0.746	0.871	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

APOL5–LUAD (DFS)

Open the LUAD breakdown →