APOL5

Across TCGA pan-cancer cohorts, APOL5 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of APOL5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOL5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOL5 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

KIRC, BRCA, and KICH are the cancer types where APOL5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOL5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.539	<.001	12	view →
BRCA	All	II,III,IV	−0.131	<.001	6	view →
KICH	All	All	+0.145	.001	5	view →
COAD	All	II,III,IV	+0.041	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

APOL5–KIRC

Open the KIRC breakdown →