APOL5

Across TCGA patient cohorts, APOL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,129 significant associations in total. STAD shows the largest number of these associations.

The most reproducible APOL5-associated GO terms across cancer lineages are Blood vessel endothelial cell migration, Endothelial cell migration, and Vascular endothelial growth factor signaling pathway. Each is linked with APOL5 in more than 19 cancer types. Because this analysis shows association rather than direction, both APOL5-to-partner and partner-to-APOL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blood vessel endothelial cell migration grouped by APOL5-low versus APOL5-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL5→partner) and Y-score (partner→APOL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Blood vessel endothelial cell migration →	+0.066	+0.094	.006	.002	3	19
SCLC	Endothelial cell migration →	+0.056	+0.088	.003	<.001	3	19
TGCT	Vascular endothelial growth factor signaling pathway →	+0.084	+0.455	<.001	<.001	3	18
SCLC	Negative regulation of DNA-binding transcription factor activity →	+0.057	+0.136	<.001	<.001	3	18
SCLC	Regulation of endothelial cell migration →	+0.063	+0.095	.001	.004	2	19
SCLC	Regulation of epithelial cell migration →	+0.049	+0.085	.007	.007	1	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,129 associations by consensus.

Blood vessel endothelial cell migration by APOL5 expression — SCLC

Explore this box plot interactively →