APOL5

Across TCGA patient cohorts, APOL5 protein abundance is significantly associated with the RNA expression of many other genes, with 5,835 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APOL5-associated genes across cancer lineages are TMEM145, SUZ12, and STIM1-AS1. Each is linked with APOL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOL5-to-partner and partner-to-APOL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL5 versus TMEM145 in GBM, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL5→partner) and Y-score (partner→APOL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM145 →	-0.754	-0.560	.002	<.001	3	3
LSCC	SUZ12 →	-0.556	-0.952	.003	<.001	3	3
UCEC	STIM1-AS1 →	+0.539	+0.900	.001	.001	3	3
UCEC	QSER1 →	-0.628	-1.128	<.001	<.001	3	3
GBM	WDR62 →	-0.792	-0.566	.001	.002	3	3
UCEC	RAD54L →	-0.923	-1.049	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,835 associations by consensus.

APOL5 vs TMEM145 — GBM

Explore this scatter interactively →