APOL5

Across TCGA patient cohorts, APOL5 mutation is significantly associated with the RNA expression of many other genes, with 797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL5-associated genes across cancer lineages are RN7SKP181, AMDHD2, and NOL6. Each is linked with APOL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOL5-to-partner and partner-to-APOL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by APOL5-low versus APOL5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL5→partner) and Y-score (partner→APOL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP181 →	+0.114	+4.685	<.001	.007	3	3
UCEC	AMDHD2 →	+0.491	+2.243	.006	.006	3	2
SKCM	NOL6 →	+0.452	+2.813	.008	.001	3	2
UCEC	BTNL9 →	-0.911	-2.896	.008	.002	3	2
UCEC	SLC27A4 →	+0.479	+3.409	.004	.004	3	2
UCEC	CTU2 →	+0.553	+3.609	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 797 associations by consensus.

RN7SKP181 by APOL5 expression — BLCA

Explore this box plot interactively →