APOL5

Across TCGA patient cohorts, APOL5 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL5-associated genes across cancer lineages are JNK_pT183_Y185, Fibronectin, and JNK2. Each is linked with APOL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOL5-to-partner and partner-to-APOL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by APOL5-low versus APOL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL5→partner) and Y-score (partner→APOL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.173	-2.321	.027	.034	3	2
UCEC	Fibronectin →	-0.368	-3.160	.016	.019	3	1
UCEC	JNK2 →	+0.296	+3.700	.001	.001	3	1
UCEC	Lck →	+0.319	+2.584	<.001	.011	3	1
UCEC	PDK1_pS241 →	+0.158	+1.887	.047	.031	3	1
UCEC	Annexin-1 →	+0.588	+3.019	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

JNK_pT183_Y185 by APOL5 expression — UCEC

Explore this box plot interactively →