APOL5

Across TCGA cell cohorts, APOL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 714 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APOL5-associated GO terms across cancer lineages are Negative regulation of epithelial cell differentiation, Cell-substrate junction assembly, and Negative regulation of calcineurin-NFAT signaling cascade. Each is linked with APOL5 in more than 3 cancer types. Because this analysis shows association rather than direction, both APOL5-to-partner and partner-to-APOL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of epithelial cell differentiation grouped by APOL5-low versus APOL5-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL5→partner) and Y-score (partner→APOL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of epithelial cell differentiation →	-0.058	-0.013	.007	.005	3	4
BREAST	Cell-substrate junction assembly →	+0.136	+0.014	<.001	.003	3	3
BREAST	Negative regulation of calcineurin-NFAT signaling cascade →	+0.138	+0.013	.004	.005	3	3
CNS	Skeletal muscle atrophy →	-0.587	-0.011	<.001	.001	3	3
CNS	Regulation of postsynaptic neurotransmitter receptor diffusion trapping →	+0.091	+0.010	.006	.004	3	3
BLOOD_Lymphoma	Detection of bacterium →	-0.168	-0.254	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 714 associations by consensus.

Negative regulation of epithelial cell differentiation by APOL5 expression — CNS

Explore this box plot interactively →