APOL2

Across TCGA patient cohorts, APOL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,036 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible APOL2-associated proteins across cancer lineages are NMI, GBP1, and PARP14. Each is linked with APOL2 in more than 8 cancer types. Because this analysis shows association rather than direction, both APOL2-to-partner and partner-to-APOL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL2 versus NMI in UCEC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL2→partner) and Y-score (partner→APOL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NMI →	+0.487	+0.735	<.001	.007	3	9
HNSC	GBP1 →	+0.731	+0.775	<.001	<.001	3	9
OV	PARP14 →	+0.415	+0.919	<.001	<.001	3	8
UCEC	PSMB10 →	+0.548	+0.898	<.001	.001	3	8
OV	PSMB9 →	+0.623	+1.321	<.001	<.001	3	8
HNSC	WARS1 →	+0.813	+0.888	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,036 associations by consensus.

APOL2 vs NMI — UCEC

Explore this scatter interactively →