APOL2

Across TCGA pan-cancer cohorts, APOL2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of APOL2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOL2 is over-expressed in tumor.

KIRC, HNSC, and LIHC are the cancer types where APOL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.403	<.001	12	view →
HNSC	All	All	+1.106	<.001	10	view →
LIHC	All	All	+0.592	<.001	7	view →
THCA	Male	II,III,IV	+0.498	.001	7	view →
STAD	All	II,III,IV	+0.954	<.001	6	view →
KIRP	All	All	+0.608	.004	6	view →
CHOL	All	All	+1.157	<.001	5	view →
BRCA	All	All	+0.280	<.001	4	view →
KICH	Female	All	+0.464	.004	3	view →
ESCA	All	All	+1.442	.009	2	view →
READ	Male	All	+0.893	.020	2	view →
LUAD	Female	II,III,IV	+0.384	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

APOL2–KIRC

Open the KIRC breakdown →