APOL2

Across TCGA patient cohorts, APOL2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL2-associated genes across cancer lineages are FoxM1, mTOR_pS2448, and Myosin-IIa_pS1943. Each is linked with APOL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL2-to-partner and partner-to-APOL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by APOL2-low versus APOL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL2→partner) and Y-score (partner→APOL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.284	+2.817	.045	.036	3	1
UCEC	mTOR_pS2448 →	-0.212	-3.169	.009	.020	3	1
UCEC	Myosin-IIa_pS1943 →	+0.225	+3.183	.047	.010	3	1
UCEC	N-Cadherin →	-0.247	-3.169	.033	.020	3	1
UCEC	PCNA →	+0.370	+3.169	.001	.018	3	1
UCEC	ATM →	-0.561	-3.169	.024	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FoxM1 by APOL2 expression — UCEC

Explore this box plot interactively →