APOL2

Across TCGA cell cohorts, APOL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,536 significant associations in total. BONE shows the largest number of these associations.

The most reproducible APOL2-associated GO terms across cancer lineages are Acute-phase response, Antigen processing and presentation of endogenous peptide antigen via MHC class I, and Interleukin-10-mediated signaling pathway. Each is linked with APOL2 in more than 15 cancer types. Because this analysis shows association rather than direction, both APOL2-to-partner and partner-to-APOL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acute-phase response grouped by APOL2-low versus APOL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL2→partner) and Y-score (partner→APOL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Acute-phase response →	+0.206	+1.517	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.279	+2.049	<.001	<.001	3	14
BONE	Interleukin-10-mediated signaling pathway →	+0.270	+2.123	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of endogenous antigen →	+0.283	+1.957	<.001	<.001	3	14
LIVER	T cell selection →	+0.141	+1.712	<.001	<.001	3	14
BONE	Cytolysis in another organism →	+1.500	+1.451	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,536 associations by consensus.

Acute-phase response by APOL2 expression — LUNG_SCLC

Explore this box plot interactively →