APOF

Across TCGA patient cohorts, APOF mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible APOF-associated genes across cancer lineages are CLP, pDC, and Endothelial cells. Each is linked with APOF in more than 1 cancer types. Because this analysis shows association rather than direction, both APOF-to-partner and partner-to-APOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLP grouped by APOF-low versus APOF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOF→partner) and Y-score (partner→APOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CLP →	+0.104	+3.019	.020	.019	3	1
UCEC	pDC →	+0.087	+2.839	.001	.034	3	1
SKCM	Endothelial cells →	-0.046	-2.993	.041	.037	1	2
SKCM	mv Endothelial cells →	-0.037	-2.993	.017	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CLP by APOF expression — SKCM

Explore this box plot interactively →