APOF

Across TCGA pan-cancer cohorts, APOF RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of APOF’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where APOF RNA is repressed in tumor relative to normal tissue. In most cancer types APOF is over-expressed in tumor, although a few such as LIHC and KICH show the opposite, repressed pattern.

LIHC, KICH, and KIRC are the cancer types where APOF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	−4.398	<.001	8	view →
KICH	All	All	−0.282	<.001	7	view →
KIRC	Male	II,III,IV	−0.138	<.001	7	view →
CHOL	Female	All	−8.260	<.001	5	view →
BRCA	Female	All	+0.368	.001	4	view →
LUSC	Male	All	+0.054	.005	4	view →
KIRP	Male	All	−0.117	.008	3	view →
PRAD	All	All	+2.227	<.001	2	view →
THCA	All	All	−0.043	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

APOF–LIHC

Open the LIHC breakdown →