APOF

Across TCGA cell cohorts, APOF RNA expression is significantly associated with the go_rna of many other GO terms, with 1,366 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APOF-associated GO terms across cancer lineages are Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway, Regulation of necroptotic process, and Type 2 mitophagy. Each is linked with APOF in more than 5 cancer types. Because this analysis shows association rather than direction, both APOF-to-partner and partner-to-APOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway grouped by APOF-low versus APOF-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOF→partner) and Y-score (partner→APOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.067	+0.025	.006	.006	3	6
BLOOD_Myeloma	Regulation of necroptotic process →	+0.103	+0.069	<.001	<.001	3	6
LARGE_INTESTINE	Type 2 mitophagy →	+0.100	+0.027	.001	.006	3	5
BREAST	Acylglycerol acyl-chain remodeling →	+0.226	+0.473	.002	.006	3	5
LUNG_SCLC	Positive regulation of T cell migration →	-0.135	-0.046	<.001	.007	3	4
LUNG_SCLC	Lipoxin biosynthetic process →	+0.845	+0.042	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,366 associations by consensus.

Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway by APOF expression — CNS

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