APOC4

Across TCGA patient cohorts, APOC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,756 significant associations in total. STAD shows the largest number of these associations.

The most reproducible APOC4-associated GO terms across cancer lineages are Protein methylation, Organic acid catabolic process, and Peptidyl-lysine modification. Each is linked with APOC4 in more than 14 cancer types. Because this analysis shows association rather than direction, both APOC4-to-partner and partner-to-APOC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein methylation grouped by APOC4-low versus APOC4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC4→partner) and Y-score (partner→APOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Protein methylation →	+0.044	+0.053	<.001	<.001	3	15
CHOL	Organic acid catabolic process →	+0.055	+0.155	<.001	<.001	3	14
STAD	Peptidyl-lysine modification →	+0.048	+0.058	<.001	<.001	3	14
KIRC	Regulation of protein folding →	+0.057	+0.069	<.001	<.001	3	14
ESCA	Regulation of intracellular protein transport →	+0.056	+0.078	<.001	<.001	3	14
CHOL	Nucleoside bisphosphate metabolic process →	+0.045	+0.186	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,756 associations by consensus.

Protein methylation by APOC4 expression — STAD

Explore this box plot interactively →