APOC4

Across TCGA pan-cancer cohorts, APOC4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated APOC4 data layer compared with 7 for mass-spec protein.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher APOC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOC4 expression acts as an unfavorable survival marker, although some lineages such as LAML and LIHC show a favorable association.

TGCT, KIRC, and CHOL are the cancer types where APOC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	DFS	Tertile	III,IV	0.010	1.000	<.001	90	view →
KIRC	DFS	Tertile	III,IV	0.269	0.546	.004	66	view →
CHOL	DFS	Tertile	II,III,IV	0.102	0.473	<.001	54	view →
LUSC	DFS	Tertile	All	0.580	0.767	.001	54	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
UCS	OS	Tertile	II,III,IV	0.262	0.645	.006	36	view →
LAML	DFS	Quartile	All	0.610	0.313	.018	26	view →
LIHC	DFS	Tertile	All	0.364	0.208	.011	20	view →
BLCA	OS	Tertile	II,III,IV	0.831	0.694	.023	18	view →
ACC	OS	Tertile	All	0.611	0.908	.002	15	view →
KIRP	OS	Tertile	II,III,IV	0.840	0.436	.031	14	view →
THYM	OS	Tertile	All	0.676	0.919	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

APOC4–TGCT (DFS)

Open the TGCT breakdown →