APOC4

Across TCGA patient cohorts, APOC4 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible APOC4-associated genes across cancer lineages are MIR8063, RN7SL557P, and CBLL2. Each is linked with APOC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOC4-to-partner and partner-to-APOC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8063 grouped by APOC4-low versus APOC4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC4→partner) and Y-score (partner→APOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR8063 →	+0.388	+4.513	<.001	.009	3	1
BLCA	RN7SL557P →	+0.139	+7.640	<.001	.009	3	1
SKCM	CBLL2 →	+0.034	+5.118	<.001	.001	3	1
SKCM	RNU6-179P →	+0.309	+4.867	<.001	.005	3	1
SKCM	RNU6-730P →	+0.323	+4.970	<.001	.005	3	1
SKCM	KRT18P12 →	+0.041	+4.531	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MIR8063 by APOC4 expression — SKCM

Explore this box plot interactively →