APOC4

Across TCGA cell cohorts, APOC4 RNA expression is significantly associated with the RNA expression of many other genes, with 1,123 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible APOC4-associated genes across cancer lineages are GFRAL, AGRP, and C5orf52. Each is linked with APOC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOC4-to-partner and partner-to-APOC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOC4 versus GFRAL in PANCREAS, with a Pearson correlation of 0.78.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC4→partner) and Y-score (partner→APOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GFRAL →	+0.006	+0.182	<.001	<.001	3	3
LUNG_NSCLC_LUSC	AGRP →	+0.072	+0.061	<.001	.009	3	3
LUNG_SCLC	C5orf52 →	+0.036	+0.046	.001	<.001	3	3
LARGE_INTESTINE	GOLGA6L6 →	+0.037	+0.057	.006	.009	3	2
URINARY_TRACT	OR13C5 →	+0.745	+1.025	<.001	<.001	3	2
BREAST	GALNTL5 →	+0.224	+0.369	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,123 associations by consensus.

APOC4 vs GFRAL — PANCREAS

Explore this scatter interactively →