APOC4

Across TCGA cell cohorts, APOC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 338 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible APOC4-associated GO terms across cancer lineages are Negative regulation of dendritic spine development, Hematopoietic stem cell migration, and Malate metabolic process. Each is linked with APOC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both APOC4-to-partner and partner-to-APOC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dendritic spine development grouped by APOC4-low versus APOC4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC4→partner) and Y-score (partner→APOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of dendritic spine development →	+0.089	+0.089	.001	.001	2	4
LARGE_INTESTINE	Hematopoietic stem cell migration →	-0.731	-0.037	.009	.008	3	3
LARGE_INTESTINE	Malate metabolic process →	+0.118	+0.039	<.001	.006	3	3
BLOOD_Leukemia	Cellular response to environmental stimulus →	-0.017	-0.080	.005	.001	3	2
BLOOD_Leukemia	Morphogenesis of an epithelial sheet →	-0.039	-0.118	.002	.002	3	2
BLOOD_Leukemia	Positive regulation of granulocyte differentiation →	-0.105	-0.082	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

Negative regulation of dendritic spine development by APOC4 expression — BLOOD_Leukemia

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