APOC3

Across TCGA patient cohorts, APOC3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,244 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible APOC3-associated genes across cancer lineages are FOSB, CNRIP1, and THBS1. Each is linked with APOC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both APOC3-to-partner and partner-to-APOC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOC3 versus FOSB in OV, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC3→partner) and Y-score (partner→APOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FOSB →	+1.593	+0.537	<.001	<.001	3	7
OV	CNRIP1 →	+0.647	+0.718	.003	<.001	3	7
OV	THBS1 →	+1.991	+1.016	<.001	<.001	3	7
COAD	ITPRIP →	+0.660	+0.713	<.001	<.001	3	7
OV	EGR1 →	+1.959	+0.822	<.001	<.001	3	6
OV	ZFP36 →	+1.421	+0.859	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,244 associations by consensus.

APOC3 vs FOSB — OV

Explore this scatter interactively →