APOC3

Across TCGA cell cohorts, APOC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 961 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible APOC3-associated GO terms across cancer lineages are Negative regulation of cholesterol import, Regulation of cholesterol import, and Positive regulation of purine nucleotide biosynthetic process. Each is linked with APOC3 in more than 8 cancer types. Because this analysis shows association rather than direction, both APOC3-to-partner and partner-to-APOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cholesterol import grouped by APOC3-low versus APOC3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC3→partner) and Y-score (partner→APOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of cholesterol import →	+1.801	+3.658	<.001	<.001	3	9
SOFT_TISSUE	Regulation of cholesterol import →	-0.240	-0.533	<.001	<.001	3	5
LIVER	Positive regulation of purine nucleotide biosynthetic process →	-0.187	-4.377	<.001	<.001	3	4
LIVER	Regulation of cilium assembly →	-0.064	-5.070	<.001	<.001	3	4
LIVER	Positive regulation of ATP biosynthetic process →	-0.185	-4.043	<.001	<.001	3	4
LIVER	Positive regulation of nucleotide biosynthetic process →	-0.187	-4.377	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 961 associations by consensus.

Negative regulation of cholesterol import by APOC3 expression — LIVER

Explore this box plot interactively →