APOC1

Across TCGA pan-cancer cohorts, APOC1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated APOC1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher APOC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where APOC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.808	1.000	.001	30	view →
CCRCC	DFS	Median	III,IV	0.894	0.529	.001	28	view →
PDAC	OS	Tertile	All	0.724	1.000	.002	15	view →
GBM	DFS	Quartile	All	0.622	0.182	.002	12	view →
OV	DFS	Median	All	0.938	0.620	.022	8	view →
HNSC	DFS	Quartile	III,IV	1.000	0.882	.041	5	view →
LUAD	OS	Quartile	II,III,IV	0.243	0.702	.045	2	view →
LSCC	DFS	Quartile	All	0.894	0.741	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

APOC1–UCEC (DFS)

Open the UCEC breakdown →