Across TCGA pan-cancer cohorts, APOBR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated APOBR data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher APOBR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated APOBR expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where APOBR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.298	0.808	.013	4	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	4	view →
PDAC	OS	Quartile	IV	0.222	0.962	.038	4	view →
GBM	DFS	Tertile	All	0.653	0.811	.043	2	view →
CCRCC	DFS	Median	II,III,IV	0.988	0.813	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: APOBR tumor-vs-normal RNA expression · all APOBR data types