APOBR

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, APOBR mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBR-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and 14-3-3_beta. Each is linked with APOBR in more than 3 cancer types. Because this analysis shows association rather than direction, both APOBR-to-partner and partner-to-APOBR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBR→partner) and Y-score (partner→APOBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+0.608+2.434.001.00134
UCECATM →-0.433-2.401.003.00233
UCEC14-3-3_beta →-0.088-2.295.006.00532
UCECeIF4E →+0.154+1.887.024.02932
SKCMERK2 →+0.190+1.700.032.04332
UCECHeregulin →-0.129-2.070.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration